My background is in computational biology, genomic technology development, and molecular biology. While my primary day to day work these days is computational biology and tool development, I also have a broad background in developing novel technologies within single-cell genomics and genetic screens. I love working with cross-functional teams and being heavily integrated at every stage of the projects I work on. I'm most excited when working on or applying new and interesting technologies with relatively unexplored strategies for processing and/or downstream data analysis.
I'm currently computational biologist at Tune Therapeutics, focusing on early stage research and development aimed at in-vivo and ex-vivo applications of gene activation or repression and target discovery.
Prior to joining Tune, I was a computational biologist at 10x genomics, where I made key contributions to several products including Single Cell Fixed RNA Profiling (now Single Cell Gene Expression Flex) (many contributions including computational biology lead and early-stage/core team member), Visium for FFPE, Xenium In Situ, Targeted Gene Expression, Chromium X Series instruments, and the low throughput kit configurations for various 10x assays. I acted as a project lead for a group of 3-4 computational biologists and made individual contributions to probe design algorithms/software tools for in-situ ligation based assays and hybrid capture, internal and customer-facing analysis software development utilizing python, rust, and martian, and regularly contributed bespoke analyses to help inform and drive forward product development. I worked extensively within cross-functional teams helping contribute to a variety of challenging problems from both the perspective of both a computational biologist and molecular biologist. I also co-authored several patents covering computational methods and assays.
I was also an NSF graduate research fellow at UW Genome Sciences, working on novel applications of single-cell technologies with Jay Shendure and Cole Trapnell. I was also a computational biology intern and consultant for 10x Genomics during graduate school.
Before graduate school, I worked in Daniel MacArthur's group at Massachusetts General Hospital and the Broad Institute, predominantly focusing on the identification and annotation of multi-nucleotide variants in ExAC.
Please download my CV (last updated April 2022) to learn more about me and/or get in touch via email.
1st Author; Science 2022Domcke, Hill, Daza, et al.; A human cell atlas of fetal chromatin accessibility
2nd Author; Nature Genetics 2019McFaline-Figueroa, et al.; A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition
2nd Author; Cell 2019 (bioRxiv 2018)Gasperini, et al.; A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens
Middle Author; Science 2018Cao, et al.; Joint profiling of chromatin accessibility and gene expression in thousands of single cells
1st Author; Nature Methods 2018Hill and McFaline-Figueroa, et al.; On the design of CRISPR-based single-cell molecular screens
2nd Author; Nature Methods 2017Qiu, et al.; Single-cell mRNA quantification and differential analysis with Census
3rd Author; Cell 2016Snyder and Kircher, et al.; Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin